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Structure prediction with FAMS for proteins screened critically to autoimmune diseases based upon bioimformatics
https://ipsj.ixsq.nii.ac.jp/records/82650
https://ipsj.ixsq.nii.ac.jp/records/82650032d4d9e-257d-456c-b086-bdeab53f62e8
名前 / ファイル | ライセンス | アクション |
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Copyright (c) 2012 by the Information Processing Society of Japan
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オープンアクセス |
Item type | SIG Technical Reports(1) | |||||||
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公開日 | 2012-06-21 | |||||||
タイトル | ||||||||
タイトル | Structure prediction with FAMS for proteins screened critically to autoimmune diseases based upon bioimformatics | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Structure prediction with FAMS for proteins screened critically to autoimmune diseases based upon bioimformatics | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18gh | |||||||
資源タイプ | technical report | |||||||
著者所属 | ||||||||
Department of Physics, Chuo University | ||||||||
著者所属 | ||||||||
Department of Biological Sciences, Chuo University | ||||||||
著者所属 | ||||||||
Department of Biological Sciences, Chuo University | ||||||||
著者所属 | ||||||||
Department of Physics, Chuo University | ||||||||
著者所属(英) | ||||||||
en | ||||||||
Department of Physics, Chuo University | ||||||||
著者所属(英) | ||||||||
en | ||||||||
Department of Biological Sciences, Chuo University | ||||||||
著者所属(英) | ||||||||
en | ||||||||
Department of Biological Sciences, Chuo University | ||||||||
著者所属(英) | ||||||||
en | ||||||||
Department of Physics, Chuo University | ||||||||
著者名 |
Shigeharu, Ishida
× Shigeharu, Ishida
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著者名(英) |
Shigeharu, Ishida
× Shigeharu, Ishida
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論文抄録 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Drug discovery for autoimmune diseases is recently recognized to be an important task. In this study, we try to perform structure prediction of proteins whose gene promoter regions were previous reported to be specifically methelysed or de-methylased commonly for three autoimmune diseases, systemic lupus erythematosus, rheumatoid arthritis, and dermatomyositis. FAMS were employed for this purpose and we can predict three dimensional structure with significantly small enough P-values. Most of them are suggested to be self immunology related proteins and will be important drug target candidates. We also found some proteins which form complex with each other. The possibility of a new drug target, i.e., suppression of protein complex formation is suggested. | |||||||
論文抄録(英) | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Drug discovery for autoimmune diseases is recently recognized to be an important task. In this study, we try to perform structure prediction of proteins whose gene promoter regions were previous reported to be specifically methelysed or de-methylased commonly for three autoimmune diseases, systemic lupus erythematosus, rheumatoid arthritis, and dermatomyositis. FAMS were employed for this purpose and we can predict three dimensional structure with significantly small enough P-values. Most of them are suggested to be self immunology related proteins and will be important drug target candidates. We also found some proteins which form complex with each other. The possibility of a new drug target, i.e., suppression of protein complex formation is suggested. | |||||||
書誌レコードID | ||||||||
収録物識別子タイプ | NCID | |||||||
収録物識別子 | AA12055912 | |||||||
書誌情報 |
研究報告バイオ情報学(BIO) 巻 2012-BIO-29, 号 12, p. 1-6, 発行日 2012-06-21 |
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Notice | ||||||||
SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc. | ||||||||
出版者 | ||||||||
言語 | ja | |||||||
出版者 | 情報処理学会 |