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The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts
https://mdu.repo.nii.ac.jp/records/2440
https://mdu.repo.nii.ac.jp/records/24404a3b7a46-cf43-4134-8d2b-82b8a481fa2c
名前 / ファイル | ライセンス | アクション |
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学位論文審査の結果及び最終試験の結果の要旨 (135.1 kB)
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学位論文の要旨 (118.7 kB)
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Item type | 学位論文 / Thesis or Dissertation正(1) | |||||
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公開日 | 2015-10-26 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Osteoclast | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Actin ring | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Bone resorption | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Dynamin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Dynasore | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
資源タイプ | thesis | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | ダイナミン阻害剤ダイナソアは破骨細胞のアクチンリングを速やかに破壊することで骨吸収を抑制する | |||||
著者 |
Thirukonda, Gnanasagar Janardhanan
× Thirukonda, Gnanasagar Janardhanan |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The cytoskeletal organization of osteoclasts is required for bone resorption. Binding of dynamin with guanosine triphosphate (GTP) was previously suggested to be required for the organization of the actin cytoskeleton. However, the role of the GTPase activity of dynamin in the organization of the actin cytoskeleton as well as in the bone-resorbing activity of osteoclasts remains unclear. This study investigated the effects of dynasore, an inhibitor of the GTPase activity of dynamin, on the bone-resorbing activity of and actin ring formation in mouse osteoclasts in vitro and in vivo. Dynasore inhibited the formation of resorption pits in osteoclast cultures by suppressing actin ring formation and rapidly disrupting actin rings in osteoclasts. A time-lapse image analysis showed that dynasore shrank actin rings in osteoclasts within 30 min. The intraperitoneal administration of dynasore inhibited receptor activator of nuclear factor κB ligand (RANKL)-induced trabecular bone loss in mouse femurs. These in vitro and in vivo results suggest that the GTPase activity of dynamin is critical for the bone-resorbing activity of osteoclasts and that dynasore is a seed for the development of novel anti-resorbing agents. | |||||
書誌情報 |
en : Journal of bone and mineral metabolism 巻 34, 号 4, p. 395-400, 発行日 2016-07 |
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情報源 | ||||||
関連名称 | 雑誌掲載論文(電子版) | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0914-8779 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10747551 | |||||
権利 | ||||||
権利情報 | © The Japanese Society for Bone and Mineral Research and Springer Japan 2015 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://link.springer.com/article/10.1007%2Fs00774-015-0683-1 | |||||
関連名称 | Springer LINK | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/26063501 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00774-015-0683-1 | |||||
関連名称 | info:doi/10.1007/s00774-015-0683-1 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
学位授与年度 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2015 | |||||
報告番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 甲第173号 | |||||
学位授与番号 | ||||||
学位授与番号 | 33602甲第173号 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2015-09-10 | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与大学 | ||||||
学位授与機関名 | 松本歯科大学 |