WEKO3
インデックスリンク
-
RootNode
アイテム
<Review>MET-88 : Sarcoplastic Reticulum Ca^<2+>-Uptake Stiumlator for Treating Chronic Heart Failure
https://gifu-pu.repo.nii.ac.jp/records/12042
https://gifu-pu.repo.nii.ac.jp/records/120421356fa43-6b8f-4b4b-b1c8-91f682803932
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000073927.pdf (745.4 kB)
|
|
| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2000-06-30 | |||||
| タイトル | ||||||
| タイトル | <Review>MET-88 : Sarcoplastic Reticulum Ca^<2+>-Uptake Stiumlator for Treating Chronic Heart Failure | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 著者名(英) |
KURIMOTO, Tsukasa
× KURIMOTO, Tsukasa× ASAKA, Naomasa× MAEDA, Toshimatsu× IRIMURA, Kenji× MATSUURA, Naosuke |
|||||
| 著者所属(日) | ||||||
| 値 | 大鵬薬品工業株式会社 製薬センター 薬理研究所/// | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Sec of Pharmacology Research Lab. TOKUSHIMA RESEARCH CENTER TAIHO PHARMACEUTICAL CO., LTD./// | |||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | MET-88,an inhibitor of γ-butyrobetaine hydroxylase, can be characterized as a unique cardioprotective agent for the treatment of congestive heart failure (CHF) with an ability to regulate the activity of SR Ca^<2+>-ATPase. MET-88 protected the hypoxic and ischemic myocardium due to the modulation of myocardial metabolism and improved cardiac remodeling and hypertrophy as effectively as captopril. MET-88 also increased the failed Ca^<2+>-ATPase activity in the Sarcoplastic reticulum (SR), which increase might have resulted from ATP synthesis through glycolysis. These effects of MET-88 may be expected to improve mortality, prognosis, and exercise intolerance in CHF patients. In summary, MET-88 may be a useful drug for the treatment of CHF. | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00053514 | |||||
| 書誌情報 |
岐阜藥科大學紀要 en : The annual proceedings of Gifu College of Pharmacy 巻 49, p. 45-52, 発行日 2000-06-30 |
|||||
