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ラット無毛部皮膚より単離したメルケル細胞の大コンダクタンスCa²⁺依存性K⁺電流
https://doi.org/10.15069/00000845
https://doi.org/10.15069/00000845109dba95-8bfe-4f0d-8817-4d612cb222bc
名前 / ファイル | ライセンス | アクション |
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KJ00008606519 (1.1 MB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2013-03-25 | |||||
タイトル | ||||||
タイトル | ラット無毛部皮膚より単離したメルケル細胞の大コンダクタンスCa²⁺依存性K⁺電流 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Large-conductance Ca²⁺-activated K⁺ currents of Merkel cells dissociated from rat glabrous skin | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | メルケル細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 大コンダクタンスCa依存性K電流 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | パッチクランプ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 無毛部皮膚 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Merkel cell | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | large-conductance Ca2+-activated K+ | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | patch clamp | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | glabrous skin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15069/00000845 | |||||
ID登録タイプ | JaLC | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
著者名(日) |
山下, 由朗
× 山下, 由朗× 齋藤, 真之介× 内田, 憲之 |
|||||
著者名よみ |
ヤマシタ, ヨシロウ
× ヤマシタ, ヨシロウ× サイトウ, シンノスケ× ウチダ, ノリユキ |
|||||
著者名(英) |
YAMASHITA, Yoshiro
× YAMASHITA, Yoshiro× SAITO, Shinnosuke× UCHIDA, Noriyuki |
|||||
著者所属(日) | ||||||
九州保健福祉大学保健科学部視機能療法学科 | ||||||
著者所属(日) | ||||||
九州保健福祉大学保健科学部視機能療法学科 | ||||||
著者所属(日) | ||||||
九州保健福祉大学保健科学部視機能療法学科 | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Orthoptics and Visual Science, School of Health Science, Kyushu University of Health and Welfare | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Orthoptics and Visual Science, School of Health Science, Kyushu University of Health and Welfare | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Orthoptics and Visual Science, School of Health Science, Kyushu University of Health and Welfare | ||||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | This study investigated the Ca2+-activated K+ currents (KCa) of Merkel cells, which were freshly dissociated from rat glabrous skin, using whole-cell and excised patch configurations of the patch clamp technique. With the whole-cell voltage clamp, the application of slow (50 mV/s) voltage ramps from -100 to +100 mV produced an N-shaped current-voltage (I-V) relationship. Maximum current activation occurred at +38.0 ± 10.6 mV (N = 14). Replacement of extracellular Ca2+ by Mg2+ and the addition of 2 mM EGTA abolished the N-shaped I-V relationship, and 1 mM TEA reduced it to < 40%. Using inside-out patches with symmetrical 150 mM KCl solutions, channels were observed with a slope conductance of 280 pS and a reversal potential of 0 mV. Reducing the [K+]o to 5 mM shifted the reversal potential, which was expected for a K+ selective channel. The channel open-state probability (Po) was increased by increasing cytosolic [Ca2+]i. Po also increased with depolarization. These data indicate the presence of large-conductance Ca2+-activated K+ (BKCa) channels in Merkel cells. | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11490417 | |||||
書誌情報 |
九州保健福祉大学研究紀要 en : Journal of Kyushu University of Health and Welfare 巻 14, p. 143-148, 発行日 2013-03 |