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Bio-inspired Janus composite nanoscroll for on-demand tumor targeting
https://doi.org/10.15015/00001406
https://doi.org/10.15015/000014065a4dbf0f-7ebd-49ee-93c6-9d9fed18992b
名前 / ファイル | ライセンス | アクション |
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Bio-inspired Janus composite nanoscroll for on-demand tumor targeting (2.5 MB)
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Copyright©2018 by Yokohama City University
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-10-09 | |||||
タイトル | ||||||
タイトル | Bio-inspired Janus composite nanoscroll for on-demand tumor targeting | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.15015/00001406 | |||||
ID登録タイプ | JaLC | |||||
著者 |
キム, ジョンファン
× キム, ジョンファン× Kim, Jeong-Hwan |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Inspired by the responsive characteristics of natural fibrous counterparts, triple stimuli, pH-, drug-, and near-infrared (NIR) light-responsive Janus composite nanosheets (JCNs) were investigated. The nanosheets consisted of gold islands sequentially hetero-grafted with three different biocompatible polymers (gum arabic, chitosan, and poly(ε-caprolactone)-b-polyethylene glycol (PEG-b-PCL)) that are hierarchically synthesized by a physical deposition–surface functionalization–chemical exfoliation processes. The JCNs are elastic and go through pH-controlled shape recovery activity in a reversible manner. Remarkably, by anchoring the heat-sensitive PEG-b-PCL on the chitosan side of JCNs, the JCNs are securely self-scrolled when doxorubicin molecules are loaded; and unscrolled to release the drug under remotely controlled NIR-irradiation, with negligible premature release, which mimics the structural behavior of a spore launcher in ferns. Moreover, the scrolled JCNs show exceptional photothermal stability under NIR-laser irradiation and the optical hyperthermal effect is capable of inducing death of tumor cells, as well as bright fluorescence and a targeted photothermal anti-tumor effect under two-photon fluorescence imaging. This enables complex nano-therapeutic drug vehicle development in potential cancer theranosis with low toxic side-effects. | |||||
書誌情報 |
RSC Advances en : RSC Advances 巻 21, p. 17179-17187, 発行日 2016-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2046-2069 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1039/C5RA27080D |