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miR-542-3p の過剰発現は子宮内膜症間質細胞の脱落膜化能力を低下させる
https://saitama-med.repo.nii.ac.jp/records/627
https://saitama-med.repo.nii.ac.jp/records/62770a33c8e-4e77-4b1d-8b41-b05d11a53ea8
名前 / ファイル | ライセンス | アクション |
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論文内容の要旨 (66.7 kB)
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論文審査の結果の要旨 (110.6 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2018-05-30 | |||||
タイトル | ||||||
タイトル | miR-542-3p の過剰発現は子宮内膜症間質細胞の脱落膜化能力を低下させる | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Overexpression of microRNA-542-3p attenuates the differentiating capacity of endometriotic stromal cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | decidualization | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | endometriosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mesenchymal‐to‐epithelial transition | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | microRNA | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | migration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
資源タイプ | thesis | |||||
著者 |
Sultana, Shamima
× Sultana, Shamima× Sultana, Shamima |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Endometriosis is defined as the presence of endometrial glandular and stromal cells outside of the uterine cavity. A previous study reported that microRNA (miR)-542-3p plays a critical role in eutopic endometrial decidualization. This study aims to clarify the potential role of miR-542-3p and the target gene, | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | (insulin-like growth factor-binding protein 1), in the impairment of the decidualizing capacity of human ectopic endometrial stromal cells (HEcESCs). | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In vitro analysis of primary undifferentiated and decidualizing human eutopic endometrial stromal cells (HEuESCs) and HEcESCs was conducted. The primary HEuESCs or HEcESCs were expanded in culture and decidualized with 8-bromo-cyclic adenosine monophosphate (8-bromo-cAMP) and medroxyprogesterone acetate (MPA). | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The morphological and biological differentiating capacities of the HEcESCs were markedly impaired. In contrast to the HEuESCs, the HEcESCs that were treated with the decidual stimulus retained the mesenchymal phenotype and capacity for migration. The down-regulation of miR-542-3p in the HEcESCs treatment with 8-bromo-cAMP and MPA was much weaker than that of the HEuESCs. High expression of miR-542-3p led to a significant decrease in the expression of IGFBP1 in the HEcESCs. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Impairment of the differentiating capacity by the overexpression of miR-542-3p could influence the capacity for migration and invasion of endometriotic cells in an ectopic environment. | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 埼玉医科大学 | |||||
学位授与年度 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 平成29年度 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2018-03-23 | |||||
学位授与番号 | ||||||
学位授与番号 | 32409甲第1375号 | |||||
掲載誌名 | ||||||
関連名称 | Reproductive Medicine and Biology | |||||
掲載誌情報 | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661816/ | |||||
関連名称 | 出版社サイト |