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パーキンソン病の進行度におけるDAT SPECTとMIBG 心筋シンチグラフィー所見の比較
https://saitama-med.repo.nii.ac.jp/records/633
https://saitama-med.repo.nii.ac.jp/records/63345d814d9-6c53-4032-a8be-b17122f9e5db
名前 / ファイル | ライセンス | アクション |
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論文内容の要旨 (98.0 kB)
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論文審査の結果の要旨 (114.4 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2018-05-30 | |||||
タイトル | ||||||
タイトル | パーキンソン病の進行度におけるDAT SPECTとMIBG 心筋シンチグラフィー所見の比較 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Comparison of Dopamine Transporter SPECT and 123I-MIBG Myocardial Scintigraphy to Assess Clinical Severity in Patients With Parkinson Disease. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | 3-Iodobenzylguanidine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Aged | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Aged, 80 and over | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Dopamine Plasma Membrane Transport Proteins | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Female | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Humans | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Male | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Middle Aged | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Myocardial Perfusion Imaging | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Parkinson Disease | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Radiopharmaceuticals | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Tomography, Emission-Computed, Single-Photon | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
資源タイプ | thesis | |||||
著者 |
岡野, 奈々美
× 岡野, 奈々美× Okano, Nanami |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of our study was to evaluate the use of dopamine transporter (DAT) SPECT and I-MIBG myocardial scintigraphy to determine the clinical severity of Parkinson disease (PD), with a focus on motor impairments affecting activities of daily living (ADLs). | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Data for 65 consecutive PD patients who underwent both DAT and MIBG imaging were reviewed. Associations between imaging variables and Hoehn and Yahr (H&Y) staging or self-supportive care ratings were investigated. Univariate and multivariate regression analyses were performed to determine the factors associated with ADLs. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | After applying the exclusion criteria, 45 patients were analyzed (age, 73.1 ± 9.3 years; 23 males; H&Y stage 1: n = 12, stage 2: n = 14, stage 3: n = 10, stage 4: n = 5, and stage 5: n = 4; self-supportive care rating-dependent ADLs: n = 29). Dopamine transporter variables were significantly associated with the clinical severity of PD as assessed by H&Y staging, whereas MIBG variables were not. Dopamine transporter variables gradually decreased throughout progressive stages, whereas the MIBG variables changed only in the advanced stages. In a multivariate analysis including clinical and imaging variables, both lower DAT and MIBG uptakes were significantly associated with dependent ADL status (P = 0.028 and 0.034, respectively). | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In patients with PD, DAT SPECT and MIBG myocardial scintigraphy were associated with ADL status; DAT SPECT was a stronger indicator of severity than MIBG myocardial scintigraphy in the early and middle stages. | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 埼玉医科大学 | |||||
学位授与年度 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 平成29年度 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2018-03-23 | |||||
学位授与番号 | ||||||
学位授与番号 | 32409甲第1381号 | |||||
掲載誌名 | ||||||
関連名称 | Clinical nuclear medicine | |||||
掲載誌情報 | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://insights.ovid.com/pubmed?pmid=27775946 | |||||
関連名称 | 出版社サイト |