WEKO3
アイテム
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TRIM44は乳癌患者の負の予後因子であり、NF-κBシグナル伝達を調節する
https://saitama-med.repo.nii.ac.jp/records/666
https://saitama-med.repo.nii.ac.jp/records/666d31ec6db-07a4-44ea-9e48-4b93cf85c0fc
名前 / ファイル | ライセンス | アクション |
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論文内容の要旨 (119.2 kB)
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論文審査の結果の要旨 (106.1 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2018-10-30 | |||||
タイトル | ||||||
タイトル | TRIM44は乳癌患者の負の予後因子であり、NF-κBシグナル伝達を調節する | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | TRIM44 Is a Poor Prognostic Factor for Breast Cancer Patients as a Modulator of NF-κB Signaling. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | breast cancer | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cyclin-dependent kinase 19 (CDK19) | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | matrix metallopeptidase 1 (MMP1) | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | nuclear factor kappa-B (NF-κB) signaling | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | tripartite motif-containing 44 (TRIM44) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
資源タイプ | thesis | |||||
著者 |
川端, 英孝
× 川端, 英孝× Kawabata, Hidetaka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Many of the tripartite motif (TRIM) proteins function as E3 ubiquitin ligases and are assumed to be involved in various events, including oncogenesis. In regard to tripartite motif-containing 44 (TRIM44), which is an atypical TRIM family protein lacking the RING finger domain, its pathophysiological significance in breast cancer remains unknown. We performed an immunohistochemical study of TRIM44 protein in clinical breast cancer tissues from 129 patients. The pathophysiological role of TRIM44 in breast cancer was assessed by modulating TRIM44 expression in MCF-7 and MDA-MB-231 breast cancer cells. TRIM44 strong immunoreactivity was significantly associated with nuclear grade (p = 0.033), distant disease-free survival (p = 0.031) and overall survival (p = 0.027). Multivariate analysis revealed that the TRIM44 status was an independent prognostic factor for distant disease-free survival (p = 0.005) and overall survival (p = 0.002) of patients. siRNA-mediated TRIM44 knockdown significantly decreased the proliferation of MCF-7 and MDA-MB-231 cells and inhibited the migration of MDA-MB-231 cells. Microarray analysis and qRT-PCR showed that TRIM44 knockdown upregulated CDK19 and downregulated MMP1 in MDA-MB-231 cells. Notably, TRIM44 knockdown impaired nuclear factor-kappa B (NF-κB)-mediated transcriptional activity stimulated by tumor necrosis factor α (TNFα). Moreover, TRIM44 knockdown substantially attenuated the TNFα-dependent phosphorylation of the p65 subunit of NF-κB and IκBα in both MCF-7 and MDA-MB-231 cells. TRIM44 would play a role in the progression of breast cancer by promoting cell proliferation and migration, as well as by enhancing NF-κB signaling. | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 埼玉医科大学 | |||||
学位授与年度 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 平成30年度 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2018-09-21 | |||||
学位授与番号 | ||||||
学位授与番号 | 32409甲第1396号 | |||||
掲載誌名 | ||||||
関連名称 | Int J Mol Sci. | |||||
掲載誌情報 | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.mdpi.com/1422-0067/18/9/1931 | |||||
関連名称 | 出版社サイト |