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Morphological study of the submandibular gland in the type 2 diabetes mellitus model rat
https://osaka-dent.repo.nii.ac.jp/records/47
https://osaka-dent.repo.nii.ac.jp/records/47b2c86079-7509-41c2-9b74-f7a297efc43a
名前 / ファイル | ライセンス | アクション |
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学位論文 (653.0 kB)
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論文内容要旨・審査結果要旨 (119.9 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2016-08-01 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Morphological study of the submandibular gland in the type 2 diabetes mellitus model rat | |||||
著者 |
守下, 綾香
× 守下, 綾香× Morishita, Ayaka |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | Type 2 diabetes mellitus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Submandibular gland | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HbA1c | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Microvascular corrosion cast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | GK rat | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Type 2 diabetes mellitus | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Submandibular gland | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | HbA1c | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Microvascular corrosion cast | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | GK rat | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Morphological studies of the submandibular glands in the spontaneous type 2 diabetes mellitus (DM) model rats (Goto-Kakizaki: GK) are currently lacking. We investigated the morphological differences in the submandibular gland of two kinds of rats : spontaneous type 2 DM male rats and normal Wistar male rats (control). A total of 18 rats were used in the study : 9 GK rats in the DM group (fasting blood glucose level, 240.9 ± 58.0 mg/dL ; HbA1c level, 5.8 ± 0.3%) and 9 Wistar rats in the control group (fasting blood glucose level, 108.4 ± 39.7 mg/dL ; HbA1c level, 5.1 ± 0.3%). We investigated the cross-sectional area of the serous cells (n = 3, light microscopic specimens), the acinus diameter (n = 3, surface morphology specimens), and the diameter of the capillaries around the acinus (n = 3, microvasucular corrosion cast specimens). The surface morphology and microvasucular corrosion cast specimens were investigated using a scanning electron microscope. Image and statistical analysis revealed that the cross-sectional area of the serous cell, the acinus diameter, and the capillary diameter around the acinus were significantly smaller in DM rats than in normal rats. We think that hyperglycemia caused these observed atrophic changes in the serous cells, the acinus, and the diabetic microangiopathy of capillaries around the acinus in the GK rats. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2014-03-07 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第716号 |