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Effect of VCAM-1 on the Differentiation into Osteoclast
https://osaka-dent.repo.nii.ac.jp/records/56
https://osaka-dent.repo.nii.ac.jp/records/5620c55d23-5fb6-4e65-9e90-d195a44387e3
名前 / ファイル | ライセンス | アクション |
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学位論文 (671.7 kB)
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論文内容要旨・審査結果要旨 (228.7 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2016-08-01 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Effect of VCAM-1 on the Differentiation into Osteoclast | |||||
著者 |
林, 寛
× 林, 寛× HAYASHI, Hiroshi |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | osteoclast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | FAK | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | VCAM-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RANKL | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | osteoclast | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | FAK | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | VCAM-1 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | RANKL | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In Orthodontic therapy, osteoclast precursors such as monocytes and macrophages migrate from vessels into the periodontium and then differentiate into osteoclasts, causing bone resorption. Focal adhesion kinase (FAK) is a 125-kDa non-receptor type tyrosine kinase that localizes to focal adhesions. FAK is involved in osteoclastic bone resorption. Vascular cell adhesion molecule-1 (VCAM -1) is bound to VLA-4(very late antigen-4) which is kind of the α<sub>4</sub> β1-integrin, and recruits monocytic osteoclast progenitors and elevates local osteoclast activity.In our present study we focused on VCAM-1 /α<sub>4</sub> integrin-mediated the differentiation into osteoclasts and found that this type of the differentiation was mediated through FAK. RAW267.4 expressed both α<sub>4</sub> integrins, and it was reported that expression of α<sub>4</sub> integrin and its counterreceptor, VCAM-1, was not enhanced in response to receptor activator of NF-B ligand (RANKL). Neutralizing antibodies against integrin α4 effectively inhibit the differentiation into osteoclasts and phosphorylation of FAK. These findings establish VCAM-1 regulate the differentiation into osteoclasts in bone. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2014-03-07 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第733号 |