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Rat Endothelial Cell Attachment, Behavior and Gene Expression on NaOH-treated Titanium Surfaces
https://osaka-dent.repo.nii.ac.jp/records/60
https://osaka-dent.repo.nii.ac.jp/records/60c3c8a09f-a084-4bd7-8c6f-891416426aa7
名前 / ファイル | ライセンス | アクション |
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学位論文 (525.3 kB)
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論文内容要旨・審査結果要旨 (144.3 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2016-08-01 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Rat Endothelial Cell Attachment, Behavior and Gene Expression on NaOH-treated Titanium Surfaces | |||||
著者 |
中野, 容子
× 中野, 容子× NAKANO, Yoko |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | aortic endothelial cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | titanium | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nanostructures | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | wound healing | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | aortic endothelial cells | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | titanium | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | nanostructures | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | wound healing | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of this study was to evaluate the influence of nanostructures on the surface of titanium, titanium nanosheets (TNS), on the initial attachment, proliferation, and gene expression of various functional factors by rat aortic endothelial cells (RAEC) involved in wound healing. We found that the initial attachment and proliferation of RAECs after 15, 30, 45, 60, and 120 min of culture were increased on titanium surfaces modified with TNS. We also found that the expression of intercellular adhesion molecule 1, von Willebrand, and thrombomodulin transcription factors were elevated in samples containing a TNS-modified disk in compared with unmodified titanium disks during the early stages of wound healing. Our results suggest that nanostructures on titanium surfaces stimulate RAECs to upregulate expression of angiogenic factors and adhesion molecule genes, which play an essential role in controlling inflammation and revascularization during wound healing after implantation. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2014-03-07 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第737号 |