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Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation
https://osaka-dent.repo.nii.ac.jp/records/72
https://osaka-dent.repo.nii.ac.jp/records/72e15fc2ee-619f-4567-bedd-02ba02676572
名前 / ファイル | ライセンス | アクション |
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学位論文 (563.7 kB)
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論文内容要旨・審査結果要旨 (263.1 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2016-08-01 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation | |||||
著者 |
田邊, 順一
× 田邊, 順一× Tanabe, Jun-ichi |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | adiponectin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | collagen-like peptide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | osteoblast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | microarray | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | adiponectin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | collagen-like peptide | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | osteoblast | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | microarray | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Adiponectin, an adipocyte-derived biologically active molecule, is a ∼30-kDa polypeptide containing an N-terminal signal sequence, variable domain, collagen-like domain, and C-terminal globular domain. Previously we demonstrated that full-length adiponectin up-regulated the expression of genes related to osteoblastic differentiation, although the free globular domain down-regulated them. It was hypothesized that the collagen-like domain may be involved in osteoblastic differentiation, so we investigated the effect of novel synthesized collagen-like peptide on osteoblastic differentiation of murine pro-osteoblastic cells.Microarray analysis showed that the collagen-like peptide up-regulated the genes related to various signaling pathways involved in osteoblastic differentiation. In contrast, the globular domain suppressed the above genes and induced the expression of genes related to cell morphogenesis and neurological system processes. Real-time RT-PCR for osteocalcin clarified the microarray observation. Therefore, the novel synthesized collagen-like peptide had positive action on osteoblastic differentiation. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2013-12-25 | |||||
学位授与番号 | ||||||
学位授与番号 | 乙第1582号 |