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The Effect of Phenytoin on the Matrix Metalloprotease-3 Production in HGFs
https://osaka-dent.repo.nii.ac.jp/records/113
https://osaka-dent.repo.nii.ac.jp/records/1130b462662-b55c-4198-8f78-4d56e3fc69ba
名前 / ファイル | ライセンス | アクション |
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学位論文 (737.6 kB)
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論文内容要旨・審査結果要旨 (248.7 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2016-08-01 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | The Effect of Phenytoin on the Matrix Metalloprotease-3 Production in HGFs | |||||
著者 |
香川, 真貴子
× 香川, 真貴子× Kagawa, Makiko |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phenytoin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Matrix metalloproteinase-3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human gingival fibroblast | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Special care must be taken in the orthodontic treatment of patients who are medicating with phenytoin, which has a side effect of gingival overgrowth. However, the mechanism of this side effect is not yet known in detail.Gingival overgrowth is termed hatred by inflammation, and it has been reported that when inflammation occurs during phenytoin treatment the movement of the teeth is delayed. Therefore, in the present study, it was decided to investigate the mechanisms of phenytoin by focusing on matrix metalloproteinases (MMPs) that are expressed as a result of inflammation.In this study, we demonstrated that the production of MMP-3 in TNF-α-stimulated Human gingival fibroblasts (HGFs) is suppressed by phenytoin. In addition, phenytoin suppressed the phosphorylation of NFκB in TNF-α stimulated HGFs. These results suggested that phenytoin stimulation regulated the production of MMP-3 in inflammatory HGFs, and that phenythoin stimulation involves NFκB signaling. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-03-11 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第777号 |