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Comparison of EEG analysis systems during lidocaine-induced seizure activity and administration of valproic acid in rabbits
https://osaka-dent.repo.nii.ac.jp/records/116
https://osaka-dent.repo.nii.ac.jp/records/116982a1441-ee45-4c91-87d3-5ea0bc05a523
名前 / ファイル | ライセンス | アクション |
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学位論文 (127.2 kB)
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論文内容要旨・審査結果要旨 (167.7 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2016-08-01 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Comparison of EEG analysis systems during lidocaine-induced seizure activity and administration of valproic acid in rabbits | |||||
著者 |
中田, 雅代
× 中田, 雅代× Nakata, Masayo |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aperiodic analysis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Power spectrum analysis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lidocaine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Valproic acid | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Based on algorithm differences between aperiodic and power spectrum analysis of the electroencephalogram (EEG), we hypothesized that the effects on the EEG of an antiepileptic drug would be equally well detected with either lidocaine-induced seizure by aperiodic analysis or by power spectrum analysis. However, the former is superior. EEG activity was recorded in anesthetized rabbits prior to intravenous infusion of valproic acid and lidocaine and after the onset of EEG activity. Values for delta, theta, alpha, beta, and total activity, as well as edge frequency were compared within each group, and were expressed as percent change from baseline for comparison between aperiodic and power spectrum analysis. With valproic acid, EEG changes were modest and the two methods of EEG analysis were significantly different from one another for only two of the 12 comparisons. With lidocaine, the lidocaine-induced seizure activity was associated with widespread EEG changes which were better detected by aperiodic analysis than by power spectrum analysis. Comparison between the two methods of analysis indicated significant differences for theta, alpha, and beta activity and edge frequency. These results indicate that both methods of analysis may be suitable to detect modest drug-induced EEG changes, whereas aperiodic analysis is superior for detection of widespread seizure activity. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-03-11 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第780号 |