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The Effect of Interferon-γ and Zoledronate Treatment on Alpha-Tricalcium Phosphate/Collagen Sponge-Mediated Bone-Tissue Engineering
https://osaka-dent.repo.nii.ac.jp/records/121
https://osaka-dent.repo.nii.ac.jp/records/121e8da381d-4729-4a23-9dde-d12e9147088c
名前 / ファイル | ライセンス | アクション |
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学位論文 (2.2 MB)
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論文内容要旨・審査結果要旨 (220.3 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2016-08-01 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | The Effect of Interferon-γ and Zoledronate Treatment on Alpha-Tricalcium Phosphate/Collagen Sponge-Mediated Bone-Tissue Engineering | |||||
著者 |
李, 佩祺
× 李, 佩祺× Li, Peiqi |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | bone tissue engineering | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | α-TCP/CS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inflammatory response | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RANKL | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TNF-α | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | osteoclastogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interferon-γ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | zoledronate | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Inflammatory responses are frequently associated with the expression of inflammatory cytokines and severe osteoclastogenesis, which significantly affect the efficacy of biomaterials. Recent findings have suggested that interferon (IFN)-γ and zoledronate (Zol) are effective inhibitors of osteoclastogenesis. However, little is known regarding the utility of IFN-γ and Zol in bone tissue engineering. In this study, we generated rat models by generating critically sized defects in calvarias implanted with an alpha-tricalcium phosphate/collagen sponge (α-TCP/CS). At four weeks post-implantation, the rats were divided into IFN-γ, Zol, and control (no treatment) groups. Compared with the control group, the IFN-γ and Zol groups showed remarkable attenuation of severe osteoclastogenesis, leading to a significant enhancement in bone mass. Histomorphometric data and mRNA expression patterns in IFN-γ and Zol-injected rats reflected high bone-turnover with increased bone formation, a reduction in osteoclast numbers, and tumor necrosis factor-α expression. Our results demonstrated that the administration of IFN-γ and Zol enhanced bone regeneration of α-TCP/CS implants by enhancing bone formation, while hampering excess bone resorption. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-03-11 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第785号 |