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Changes in immunoglobulin A secretion induced by sympathetic and taste stimulation in the rat submandibular gland
https://osaka-dent.repo.nii.ac.jp/records/129
https://osaka-dent.repo.nii.ac.jp/records/12931b447e5-77a1-4824-b587-cfc57177bb6b
名前 / ファイル | ライセンス | アクション |
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学位論文 (604.0 kB)
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論文内容要旨・審査結果要旨 (201.4 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2016-08-01 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Changes in immunoglobulin A secretion induced by sympathetic and taste stimulation in the rat submandibular gland | |||||
著者 |
中井, 政徳
× 中井, 政徳× Nakai, Masanori |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | SIgA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sympathetic stimulation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acidity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Submandibular gland | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We studied the influence of sympathetic nerve and taste stimulation on salivary immunoglobulin A secretion in the rat submandibular gland. Although the flow of the saliva evoked by β-adrenoceptor stimulation was very small in volume, secretion evoked by both acidity and bitterness stimulation was greater than from sympathetic stimulation. A marked secretion of peroxidase was found evoked by isoprenaline. Similar levels of SIgA secretion were evoked by each stimulus. Amylase secretion was enhanced by isoprenaline, citric acid and quinine stimulation. In particular, citric acid was significantly different compared with isoprenaline. A similar level of SIgA secretion was evoked by each of the stimuli. SIgA secretion evoked by both isoprenaline and quinine was significantly inhibited by propranolol. Propranolol had only a slight inhibitory effect on citric acid stimulation. The peroxidase level in response to isoprenaline was remarkably reduced by propranolol administration. Although propranolol was less effective on peroxidase secretion evoked by citric acid, quinineinduced peroxidase stimulation was inhibited by propranolol. However, the amylase activity evoked by acidity was weaker than that of sympathetic stimulated saliva. This differencewas attributable to the influence of the nervous system on IgA secretion through input to the submandibular gland via not only the sympathetic nerves, but also the parasympathetic nerves. These results indicate that the salivary secretion of SIgA is regulated by nerve impulses and that acidity imparts a greater effect on SIgA secretion than does solitary sympathetic stimulation alone. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2015-06-24 | |||||
学位授与番号 | ||||||
学位授与番号 | 乙第1599号 |