WEKO3
アイテム
{"_buckets": {"deposit": "fc10d00c-c5ee-43e5-b24c-eb830a06eb70"}, "_deposit": {"created_by": 16, "id": "146", "owners": [16], "pid": {"revision_id": 0, "type": "depid", "value": "146"}, "status": "published"}, "_oai": {"id": "oai:osaka-dent.repo.nii.ac.jp:00000146", "sets": ["17"]}, "author_link": ["509", "508"], "item_10006_alternative_title_1": {"attribute_name": "その他(別言語等)のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "ラットの実験的歯周炎において11β-hydroxysteroid dehydrogenase type 1の発現が増加する"}]}, "item_10006_date_granted_11": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2017-03-10"}]}, "item_10006_degree_grantor_9": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "大阪歯科大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "34408", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_10006_degree_name_8": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(歯学)"}]}, "item_10006_description_10": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_description": "2016年度", "subitem_description_type": "Other"}]}, "item_10006_description_7": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The involvement of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive glucocorticoids into active glucocorticoids intracellularly, in metabolic diseases and chronic inflammatory diseases has been elucidated. To clarify the role of 11β-HSD1 in chronic periodontitis, the expression of 11β-HSD1 was investigated in an experimental periodontitis model in rats. Experimental periodontitis was induced by silk ligature. The expression of 11β-HSD1 was examined using real time PCR. The expression of 11β-HSD1 mRNA was significantly increased in experimental periodontitis compared with the control. This result suggests that the increased expression of 11β-HSD1, which results in increased levels of intracellular glucocorticoids, may play a role in the pathophysiology of experimental periodontitis.", "subitem_description_type": "Abstract"}]}, "item_10006_dissertation_number_12": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第788号"}]}, "item_10006_version_type_18": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "中田, 貴也"}, {"creatorName": "ナカタ, タカヤ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "508", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakata, Takaya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "509", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-04-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "kou_788_txt.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "学位論文", "url": "https://osaka-dent.repo.nii.ac.jp/record/146/files/kou_788_txt.pdf"}, "version_id": "6959bc18-142d-480b-9660-0ec210ec1703"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-04-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "kou_788.pdf", "filesize": [{"value": "186.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 186000.0, "url": {"label": "論文内容要旨・審査結果要旨", "url": "https://osaka-dent.repo.nii.ac.jp/record/146/files/kou_788.pdf"}, "version_id": "47d77f80-9b8b-44c3-bc49-1c63e34115f6"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "11β-HSD1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Gulucocorticoids", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Chronic periodontitis", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats"}]}, "item_type_id": "10006", "owner": "16", "path": ["17"], "permalink_uri": "https://osaka-dent.repo.nii.ac.jp/records/146", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-04-19"}, "publish_date": "2017-04-19", "publish_status": "0", "recid": "146", "relation": {}, "relation_version_is_last": true, "title": ["The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats"], "weko_shared_id": -1}
The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats
https://osaka-dent.repo.nii.ac.jp/records/146
https://osaka-dent.repo.nii.ac.jp/records/146e42d9fb7-5b8e-4a33-aecc-067e81b77f78
名前 / ファイル | ライセンス | アクション |
---|---|---|
学位論文 (1.1 MB)
|
||
論文内容要旨・審査結果要旨 (186.0 kB)
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-04-19 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats | |||||
著者 |
中田, 貴也
× 中田, 貴也× Nakata, Takaya |
|||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 11β-HSD1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gulucocorticoids | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic periodontitis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The involvement of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive glucocorticoids into active glucocorticoids intracellularly, in metabolic diseases and chronic inflammatory diseases has been elucidated. To clarify the role of 11β-HSD1 in chronic periodontitis, the expression of 11β-HSD1 was investigated in an experimental periodontitis model in rats. Experimental periodontitis was induced by silk ligature. The expression of 11β-HSD1 was examined using real time PCR. The expression of 11β-HSD1 mRNA was significantly increased in experimental periodontitis compared with the control. This result suggests that the increased expression of 11β-HSD1, which results in increased levels of intracellular glucocorticoids, may play a role in the pathophysiology of experimental periodontitis. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-03-10 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第788号 |