WEKO3
アイテム
{"_buckets": {"deposit": "50e7c61c-e64b-425a-a668-7417eda7025b"}, "_deposit": {"created_by": 16, "id": "153", "owners": [16], "pid": {"revision_id": 0, "type": "depid", "value": "153"}, "status": "published"}, "_oai": {"id": "oai:osaka-dent.repo.nii.ac.jp:00000153", "sets": ["17"]}, "author_link": ["522", "521"], "item_10006_alternative_title_1": {"attribute_name": "その他(別言語等)のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "破骨細胞形成とp38 MAP kinase経路に対するGallotanninの影響"}]}, "item_10006_date_granted_11": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2017-03-10"}]}, "item_10006_degree_grantor_9": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "大阪歯科大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "34408", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_10006_degree_name_8": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(歯学)"}]}, "item_10006_description_10": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_description": "2016年度", "subitem_description_type": "Other"}]}, "item_10006_description_7": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We examined the effect of gallotannin on osteoclast differentiation in vitro. We found that gallotannin suppressed osteoclast differentiation in a bone marrow culture system stimulated with 1, 25 (OH)2 D3, as well as in a M-CSF/RANKL-treated BMM culture system. Also, we found that gallotannin treatment suppressed the expression of NFATc1 in RANKL-treated BMMs. To further elucidate the mechanisms underlying the suppressive effect of gallotannin on osteoclast differentiation, we examined the effects of gallotannin on RANKL- and M-CSF-mediated intracellular signaling. Although gallotannin did not affect the activation kinetics of ERK1/2 and Akt, it blunted p38 MAPK activation in RANKL-treated BMMs. We also observed the suppressive effects of gallotannin on M-CSF-induced p38 MAPK activation in BMMs that had been programmed for osteoclast differentiation by pretreatment with RANKL and low-dose M-CSF for 24 h. In other words, gallotannin specifically suppressed RANKL- and M-CSF-induced activation of the p-38 MAPK pathway. ", "subitem_description_type": "Abstract"}]}, "item_10006_dissertation_number_12": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第795号"}]}, "item_10006_version_type_18": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "細山, 有規子"}, {"creatorName": "ホソヤマ, ユキコ ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "521", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hosoyama, Yukiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "522", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-04-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "kou_795_txt_Joint.pdf", "filesize": [{"value": "2.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 2300000.0, "url": {"label": "学位論文", "url": "https://osaka-dent.repo.nii.ac.jp/record/153/files/kou_795_txt_Joint.pdf"}, "version_id": "b99f7f08-4ff6-4d99-b5ce-a1da7490b875"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-04-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "kou_795.pdf", "filesize": [{"value": "179.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 179800.0, "url": {"label": "論文内容要旨・審査結果要旨", "url": "https://osaka-dent.repo.nii.ac.jp/record/153/files/kou_795.pdf"}, "version_id": "bfef5da4-374b-4ea3-9d22-9e9a53c679b0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Osteoclast|Gallotannin|Tannin|p38 MAP kinase|NFATc1", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway"}]}, "item_type_id": "10006", "owner": "16", "path": ["17"], "permalink_uri": "https://osaka-dent.repo.nii.ac.jp/records/153", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-04-19"}, "publish_date": "2017-04-19", "publish_status": "0", "recid": "153", "relation": {}, "relation_version_is_last": true, "title": ["Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway"], "weko_shared_id": -1}
Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway
https://osaka-dent.repo.nii.ac.jp/records/153
https://osaka-dent.repo.nii.ac.jp/records/1534547a882-c7a9-4f7a-b05b-10f3a3c8774e
名前 / ファイル | ライセンス | アクション |
---|---|---|
学位論文 (2.3 MB)
|
||
論文内容要旨・審査結果要旨 (179.8 kB)
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-04-19 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway | |||||
著者 |
細山, 有規子
× 細山, 有規子× Hosoyama, Yukiko |
|||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Osteoclast|Gallotannin|Tannin|p38 MAP kinase|NFATc1 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the effect of gallotannin on osteoclast differentiation in vitro. We found that gallotannin suppressed osteoclast differentiation in a bone marrow culture system stimulated with 1, 25 (OH)2 D3, as well as in a M-CSF/RANKL-treated BMM culture system. Also, we found that gallotannin treatment suppressed the expression of NFATc1 in RANKL-treated BMMs. To further elucidate the mechanisms underlying the suppressive effect of gallotannin on osteoclast differentiation, we examined the effects of gallotannin on RANKL- and M-CSF-mediated intracellular signaling. Although gallotannin did not affect the activation kinetics of ERK1/2 and Akt, it blunted p38 MAPK activation in RANKL-treated BMMs. We also observed the suppressive effects of gallotannin on M-CSF-induced p38 MAPK activation in BMMs that had been programmed for osteoclast differentiation by pretreatment with RANKL and low-dose M-CSF for 24 h. In other words, gallotannin specifically suppressed RANKL- and M-CSF-induced activation of the p-38 MAPK pathway. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-03-10 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第795号 |