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HGF/c-Met induces cell migration of oral squamous cell carcinoma via lamellipodin
https://osaka-dent.repo.nii.ac.jp/records/154
https://osaka-dent.repo.nii.ac.jp/records/15413acf842-3fc3-4e40-93a6-727e9fc73432
名前 / ファイル | ライセンス | アクション |
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学位論文 (382.9 kB)
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論文内容要旨・審査結果要旨 (201.2 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2017-04-19 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | HGF/c-Met induces cell migration of oral squamous cell carcinoma via lamellipodin | |||||
著者 |
安井, 大樹
× 安井, 大樹× Yasui, Hiroki |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | c-Met|HGF|AG1478|SU11274|Lamellipodin|Cell migration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cell migration potency is often regulated by extracellular stimuli. We previously reported that the migration potency of the oral squamous cell carcinoma (OSCC) cell lines SAS and HSC3 have high epidermal growth factor receptor (EGFR) inhibitor sensitivity, while the migration of HSC4 is not affected. Hepatocyte growth factor (HGF)/c-Met is known as one of the signaling pathways for cell migration in some cancer cells. In this study, we demonstrated the importance of the c-Met signaling pathway for filopodia and lamellipodia formation in cell migration using HSC4. The cell migration of HSC4 used the HGF/c-Met pathway. Additionally, the EGF/EGFR pathway is not related to lamellipodia formation. The HGF/c-Met pathway is important for the formation of filopodia and lamellipodia in HSC4. Furthermore, signaling from c-Met increases the amount of lamellipodin protein, which is necessary for formation of lamellipodia. Our results suggested that signaling from the HGF/c-Met pathway increases the quantity of lamellipodin protein, and induces cell migratory capacity by inducing lamellipodia forming potency in HSC4. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-03-10 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第796号 |