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Change of Cytotoxicity Level by the Addition of Nanomaterials
https://osaka-dent.repo.nii.ac.jp/records/159
https://osaka-dent.repo.nii.ac.jp/records/15948c5b68d-8884-4d4b-913f-a05fec0dfb19
名前 / ファイル | ライセンス | アクション |
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学位論文 (1.1 MB)
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論文内容要旨・審査結果要旨 (188.2 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-04-19 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Change of Cytotoxicity Level by the Addition of Nanomaterials | |||||
著者 |
白井, 翼
× 白井, 翼× Shirai, Shirai |
|||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cytotoxicity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nanomaterial | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | zinc oxide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bis-GMA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | synergy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The development of nanomaterials has promoted a marked improvement of performance and studies on the addition of new functions. Nanomaterials may be combined in many dental component materials in the future. However, at present, the results of studies on the biologi-cal safety of nanomaterials are insufficient. Cells have an active nanomaterial uptake mecha-nism, i.e., phagocytosis, and this is completely different from the mechanism of incorporat-ing dissolved chemical substances. Moreover, products prepared with nanomaterials alone are rarely developed, and nanomaterials are likely to be added to conventional chemical sub-stances. In this case, there are no data on changes in the toxicity caused by interaction be-tween nanomaterials and dissolved chemical substances. Thus, we investigated the cytotoxi-city of nano-zinc oxide alone and changes in the cytotoxicity of Bis-GMA, which is used as a matrix resin monomer of composite resin, at its non-cytotoxic concentration. Bis-GMA cyto-toxicity increased in the nano-zinc oxide group compared with that in the control group in both 2- and 3-dimensional culture using collagen gel. It was clarified that the cytotoxicity of Bis-GMA slightly increased due to interaction in the nano-zinc oxide and Bis-GMA mixture. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-03-10 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第801号 |