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Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland
https://osaka-dent.repo.nii.ac.jp/records/165
https://osaka-dent.repo.nii.ac.jp/records/165b8180663-f436-40a4-9a0d-98def68a92f4
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2017-04-19 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland | |||||
著者 |
松下, 巧
× 松下, 巧 |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | Grhl2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SPINT1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Matriptase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Salivary gland | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Development | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Development of the salivary gland is characterized by extensive branching morphogenesis and lumen formation as well as differentiation into acinar and ductal cells. Although various molecules have been implicated in salivary gland development, transcription factors regulating the expression of those molecules and salivary gland development are largely unknown. The GRHL2 transcription factor and its target gene product SPINT1 as well as the SPINT1-regualted protease matriptase play crucial roles in epithelial development in several organs. Here we examined the expression of these epithelial regulators in developing mouse SMG. Of the three Grhl gene members, Grhl2 was the most abundant in embryonic SMG. The expression levels of GRHL2, SPINT1 and matriptase were increased during development of the gland. All of these molecules were expressed exclusively in the epithelial tissue. The present data may suggest the involvement of these molecules in SMG development and give a clue to developing a regenerative therapy of damaged salivary glands. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-03-10 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第807号 |