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Investigation of human papillomavirus infections and the expression of related genes in epithelial dysplasias and squamous cell carcinomas of the oral mucosa
https://osaka-dent.repo.nii.ac.jp/records/173
https://osaka-dent.repo.nii.ac.jp/records/1732979165e-a72f-433d-b78c-9cb2c970ffb0
名前 / ファイル | ライセンス | アクション |
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学位論文 (383.3 kB)
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論文内容要旨・審査結果要旨 (191.6 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2018-01-22 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Investigation of human papillomavirus infections and the expression of related genes in epithelial dysplasias and squamous cell carcinomas of the oral mucosa | |||||
著者 |
上原, 行博
× 上原, 行博× Uehara, Yukihiro |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human papillomavirus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Squamous cell carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oral mucosa | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p16 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p53 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rb | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We studied the prevalence of human papillomavirus (HPV) infections in patients with epithelial dysplasia and squamous cell carcinoma of the oral mucosa, as well as the expression of p53, p53 (mutant type), Rb, p16, p21 and cyclin D1. The subjects were patients with irritation fibroma (IF), mild dysplasia (MiD), moderate dysplasia (MoD), severe dysplasia (SD), carcinoma in situ (CIS), well differentiated squamous cell carcinoma (WSCC) and poorly differentiated squamous cell carcinoma (PSCC) diagnosed at Osaka Dental University Hospital. Six patients, each with one of these conditions were examined. HPV was detected by in situ hybridization (ISH). Expression of p53, p53 (mutant type), Rb, p16, p21 and cyclin D1 was assessed by immunohistochemical staining (IHC). All cases were negative for HPV by ISH. For IHC, marked expression of p53 and mutant type p53 was seen in WSCC and PSCC. We could not detect expression of p21 in CIS, WSCC or PSCC. Marked expression of Rb and cyclin D1 was seen in CIS, WSCC and PSCC. We could not detect expression of p16 in WSCC or PSCC. The results suggested that HPV infections have low correlation with oral cancer. We found that p16 is a useful indicator of HPV infection. |
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学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-12-27 | |||||
学位授与番号 | ||||||
学位授与番号 | 乙第1608号 |