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Biocompatibility of titanium surface nanostructures following chemical processing and heat treatment
https://osaka-dent.repo.nii.ac.jp/records/174
https://osaka-dent.repo.nii.ac.jp/records/174d7e58073-88b3-4a20-b7f5-80b7c54346bd
名前 / ファイル | ライセンス | アクション |
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学位論文 (3.0 MB)
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論文内容要旨・審査結果要旨 (177.9 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2018-05-17 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Biocompatibility of titanium surface nanostructures following chemical processing and heat treatment | |||||
著者 |
藤尾, 美穂
× 藤尾, 美穂 |
|||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | implant | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nanostructure | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rat MSC | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aims of the present study were to investigate alkali and heat treatment of titanium surfaces, and to evaluate the ability of such modified surfaces to improve osteogenic differentiation of rat bone marrow (RBM) cells to increase the success rate of titanium implants. To improve bone differentiation on titanium alloy implants, titania nanosheet (TNS) structures were fabricated on titanium surfaces by NaOH and heat treatment at 200, 400, 600, and 800°C. Cell behavior on heat- treated TNS-modified titanium was investigated, and the ability of the modified surfaces to affect osteogenic differentiation of RBM cells and to increase the success rate of titanium implants was evaluated. The nanoscale network structures formed by alkali etching markedly enhanced the cell adhesion and osteogenesis-related gene expression of RBM cells. Other cell behaviors, such as proliferation, alkaline phosphatase activity, osteocalcin deposition, and mineralization, were also markedly increased on heat-treated TNS-modified titanium. Our results suggest that nanostructure-modified titanium implants promote osteogenic differentiation, which may improve biointegration of these implants into alveolar bone. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-03-09 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第813号 |