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Comparison of the Influence of the Newly Synthetic Peptide and Enamel Matrix Derivative in Early Wound Healing Process of the Artificial Periodontal Tissue Defects in Rats
https://osaka-dent.repo.nii.ac.jp/records/186
https://osaka-dent.repo.nii.ac.jp/records/1867300d1b4-a672-4428-87e9-b7c2386471f5
名前 / ファイル | ライセンス | アクション |
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学位論文 (1.4 MB)
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論文内容要旨・審査結果要旨 (196.0 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2018-05-17 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Comparison of the Influence of the Newly Synthetic Peptide and Enamel Matrix Derivative in Early Wound Healing Process of the Artificial Periodontal Tissue Defects in Rats | |||||
著者 |
三木, 晴加
× 三木, 晴加 |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | new synthetic peptide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | EMD | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | deep epithelial proliferation inhibition rate | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In an animal experiment with enamel matrix derivative(EMD), which is commonly used as amaterial for periodontal tissue regeneration, a substance consistent with the partial sequence of amelogenin exon 5 was identified. Investigators synthesized a peptide with the same amino acid sequence, and examined its usefulness for periodontal tissue regeneration in vivo and in vitro. However, no in vivo experiment has compared the peptide with EMD. Periodontal tissue defects were artificially prepared in the maxillary molar region of rats, and a new synthetic peptide(new synthetic peptide group)or EMD(EMD group)was applied to the site of defect. Specimens at this site were prepared 3, 5, and 7 days after surgery, and histopathologically and immunohistochemically examined using anti-type III collagen antibody. The histopathological findings 3 days after surgery were similar among the control, new synthetic peptide, and EMD groups. Five days after surgery, the disappearance of blood clots at the site of defect was confirmed in the new synthetic peptide and EMD groups, whereas blood clots remained in the control group. Silver impregnation 7 days after surgery showed an osteoid calcified body with reticular fibers at the periphery in both the new synthetic peptide and EMD groups. Immunohistochemically, in the two groups, type III collagen appeared and attenuated earlier than in the control group. In the two groups, the deep epithelial proliferation inhibition rates 5 or 7 days after surgery were significantly lower than in the control group. Like EMD, novel synthetic peptide promoted the early wound healing process in periodontal tissues compared to the control, suggesting that it has action to accelerate periodontal regeneration. |
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学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2018-03-09 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第824号 |