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Effect of nano modified titanium surface on adsorption of rat periodontal ligament cells
https://osaka-dent.repo.nii.ac.jp/records/192
https://osaka-dent.repo.nii.ac.jp/records/192da644ea9-4415-4214-a10e-41252f85967a
名前 / ファイル | ライセンス | アクション |
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学位論文 (453.7 kB)
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論文内容要旨・審査結果要旨 (207.2 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-05-17 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Effect of nano modified titanium surface on adsorption of rat periodontal ligament cells | |||||
著者 |
原, 弓加里
× 原, 弓加里 |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | Periodontal ligament cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Titanium nanostructures | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Implant | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | When natural teeth are lost, endosseous implants anchored via intimate bone-to-implant contacts are considered an appropriate replacement. The interactions between implants and host tissues depend on several factors. In particular, a growing body of evidence has demonstrated that the surface texture of an implant influences the response of the surrounding cells. Recent studies have shown that treating titanium with aqueous NaOH produces a nanostructured surface texture termed a titanium nanosheet (TNS). Furthermore, it was recently reported that a TNS surface promoted the osteogenic differentiation of rat bone marrow cells. We investigated whether a TNS surface may improve wound healing around endosseous implants. To test this, we assessed the effects of a TNS surface on the adhesion and differentiation of rat periodontal ligament (RPL) cells in vitro. The results demonstrated that RPL cells cultured on a TNS surface showed more adhesion and higher levels of osteogenic differentiation markers (Runx2 expression, alkaline phosphatase activity, calcium deposition, and osteocalcin secretion) than cells cultured on unmodified titanium. These findings indicate that RPL cells have the potential for increased bone formation on a TNS surface. Thus, TNS surface modification may warrant consideration for use in endosseous dental implants. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2018-03-09 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第830号 |