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Bioactivity of NANOZR Induced by Alkali Treatment
https://osaka-dent.repo.nii.ac.jp/records/193
https://osaka-dent.repo.nii.ac.jp/records/193f0de7d2b-d455-4e07-a9fa-0f6fbedf48ca
名前 / ファイル | ライセンス | アクション |
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学位論文 (3.7 MB)
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論文内容要旨・審査結果要旨 (194.6 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2018-05-17 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Bioactivity of NANOZR Induced by Alkali Treatment | |||||
著者 |
西崎, 真理子
× 西崎, 真理子 |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | zirconia/alumina nano-composite|bioactivity |alkali treatment | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In recent years, zirconia has been a recognized implant material in clinical dentistry. In the present study, we investigated the performance of an alkali-modified ceria-stabilized tetragonal ZrO2 polycrystalline ceramic-based nanostructured zirconia/alumina composite (NANOZR) implant by assessing surface morphology and composition, wettability, bovine serum albumin adsorption rate, rat bone marrow (RBM) cell attachment, and capacity for inducing bone differentiation. NANOZR surfaces without and with alkali treatment served as the control and test groups, respectively. RBM cells were seeded in a microplate with the implant and cultured in osteogenic differentiation medium, and their differentiation was evaluated by measuring alkaline phosphatase (ALP) activity, osteocalcin (OCN) production, calcium deposition, and osteogenic gene expression. The alkali-treated NANOZR surface increased ALP activity, OCN production, calcium deposition, and osteogenesis-related gene expression in attached RBM cells. These data suggest that alkali treatment enhances the osteogenesis-inducing capacity of NANOZR implants and may therefore improve their biointegration into alveolar bone. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2018-03-09 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第831号 |