WEKO3
-
RootNode
アイテム
Expression of E-, P-, and N-cadherin and α-, β-, and γ-catenin with respect to invasion in ameloblastoma
https://osaka-dent.repo.nii.ac.jp/records/217
https://osaka-dent.repo.nii.ac.jp/records/21769b97614-5747-4195-923e-2b04294068cc
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
学位論文 (2.2 MB)
|
|
|
|
論文内容要旨・審査結果要旨 (248.7 kB)
|
|
| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2019-05-17 | |||||||||||
| 本文言語 | ||||||||||||
| 言語 | eng | |||||||||||
| タイトル | ||||||||||||
| タイトル | Expression of E-, P-, and N-cadherin and α-, β-, and γ-catenin with respect to invasion in ameloblastoma | |||||||||||
| 著者 |
成瀬, かおり
× 成瀬, かおり
× Naruse, Kaori
|
|||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | cadherin | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | catenin | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | ameloblastoma | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | immunohistochemistry | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Ameloblastoma consists of an odontogenic epithelium and is a benign tumor without odontogenic mesenchyme. It occurs primarily in the jawbone and exhibits locally invasive growth. To clarify the factors involved in the invasion of ameloblastoma, the expression profiles of E-, P- and N-cadherin and α-, β- and γ-catenin were examined in 39 cases of ameloblastoma by immunohistochemistry. Cadherin and catenin were expressed on tumor cell membranes. Of the examined cases, 12 exhibited reduced E-cadherin expression, 12 exhibited strong P-cadherin expression, and 7 exhibited weak expression of N-cadherin. Additionally, 20 cases exhibited reduced α-catenin expression, 8 exhibited reduced β-catenin expression, and 33 cases exhibited reduced γ-catenin expression. Reduced expression of E-cadherin was associated with decreased cell adhesion, and strong expression of P-cadherin was associated with cell proliferation. Expression of N-cadherin was related to tumor invasion and suggested involvement in epithelial mesenchymal transition. In addition, reduced α-catenin in the expression region of E-cadherin suggested an abnormal function of E-cadherin. Together, these results suggest that cadherin and catenin play important roles in the development and local invasiveness of ameloblastoma. |
|||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士（歯学） | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 34408 | |||||||||||
| 学位授与機関名 | 大阪歯科大学 | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2019-03-08 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第845号 | |||||||||||
Share
Cite as
成瀬, かおり, Naruse, Kaori, n.d., Expression of E-, P-, and N-cadherin and α-, β-, and γ-catenin with respect to invasion in ameloblastoma.
Loading...
