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Osteogenic Effects of Glucose Concentration for Human Bone Marrow Stromal Cells after Stimulation with Porphyromonas gingivalis Lipopolysaccharide.
https://osaka-dent.repo.nii.ac.jp/records/260
https://osaka-dent.repo.nii.ac.jp/records/2607add1e30-4efc-4a8c-9568-cd9f8fed3c64
| 名前 / ファイル | ライセンス | アクション |
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学位論文 (3.2 MB)
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論文内容要旨・審査結果要旨 (292.0 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2020-04-28 | |||||||||||
| 本文言語 | ||||||||||||
| 言語 | eng | |||||||||||
| タイトル | ||||||||||||
| タイトル | Osteogenic Effects of Glucose Concentration for Human Bone Marrow Stromal Cells after Stimulation with Porphyromonas gingivalis Lipopolysaccharide. | |||||||||||
| 著者 |
塩見, 慧
× 塩見, 慧
× Shiomi, Kei
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| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Bone marrow cells | |||||||||||
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| 主題Scheme | Other | |||||||||||
| 主題 | Hyperglycemia | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Porphyromonas gingivalis | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Chronic inflammation contributes to the development of DM and DM-associated complications. Hyperglycemia is a hallmark of DM and may contribute to sustained inflammation by increasing the levels of proinflammatory cytokines. However, the mechanisms by which bone-related complications develop in DM after stimulation by the Porphyromonas gingivalis lipopolysaccharide (P. gingivalis LPS) remain unknown. We evaluated the effect of high glucose levels on the biomineralization and inflammation markers in a human osteoblastic cell line, after stimulation with LPS from P. gingivalis. We treated cells with glucose at concentrations 5.5, 8.0, 12 and 24 mM after stimulation with P. gingivalis LPS (1.0 mg/ml) and determined its effects on cell proliferation, alkaline phosphatase (ALP) activity, osteocalcin (OCN) production, calcium deposition, inflammatory cytokines, and osteogenic cytokines. . High glucose concentration decreased hard tissue formation after stimulation by P. gingivalis LPS. Understanding the effect of glucose on osteoblast differentiation and Ca deposition might provide a better understanding of the development and prevention of periodontitis associated with diabetes. | |||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士（歯学） | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 34408 | |||||||||||
| 学位授与機関名 | 大阪歯科大学 | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2020-03-06 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第877号 | |||||||||||
