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Aging markers in human urine: A comprehensive, non‐targeted LC‐MS study
https://oist.repo.nii.ac.jp/records/1877
https://oist.repo.nii.ac.jp/records/1877689bfe72-b8aa-440e-b8ae-f6f02b5b56ae
名前 / ファイル | ライセンス | アクション |
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fba.2020-00047 (1.4 MB)
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Creative Commons Attribution-NonCommercial 4.0 International(https://creativecommons.org/licenses/by-nc/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-01-15 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Aging markers in human urine: A comprehensive, non‐targeted LC‐MS study | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | creatinine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | glutathione | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | human endocrine aging | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | LC-MS | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | non-targeted metabolomics | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | pseudouridine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | urinary age markers | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Teruya, Takayuki
× Teruya, Takayuki× Goga, Haruhisa× Yanagida, Mitsuhiro |
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書誌情報 |
en : FASEB BioAdvances 巻 2, 号 12, p. 720-733, 発行日 2020-10-21 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Metabolites in human biofluids document the physiological status of individuals. We conducted comprehensive, non‐targeted, non‐invasive metabolomic analysis of urine from 27 healthy human subjects, comprising 13 young adults (30 ± 3 years) and 14 seniors (76 ± 4 years). Quantitative analysis of 99 metabolites revealed 55 that displayed significant differences in abundance between the two groups. Forty‐four did not show a statistically significant relationship with age. These include 13 standard amino acids, 5 methylated, 4 acetylated, and 9 other amino acids, 6 nucleosides, nucleobases, and derivatives, 4 sugar derivatives, 5 sugar phosphates, 4 carnitines, 2 hydroxybutyrates, 1 choline, and 1 ethanolamine derivative, and glutathione disulfide. Abundances of 53 compounds decreased, while 2 (glutathione disulfide, myo‐inositol) increased in elderly people. The great majority of age‐linked markers were highly correlated with creatinine. In contrast, 44 other urinary metabolites, including urate, carnitine, hippurate, and betaine, were not age‐linked, neither declining nor increasing in elderly subjects. As metabolite profiles of urine and blood are quite different, age‐related information in urine offers additional valuable insights into aging mechanisms of endocrine system. Correlation analysis of urinary metabolites revealed distinctly inter‐related groups of compounds. | |||||
出版者 | ||||||
出版者 | Federation of American Societies for Experimental Biology. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2573-9832 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33336159 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1096/fba.2020-00047 | |||||
権利 | ||||||
権利情報 | © 2020 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://faseb.onlinelibrary.wiley.com/doi/10.1096/fba.2020-00047 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |