WEKO3
アイテム
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Divalent metal transporter-related protein restricts animals to marine habitats
https://oist.repo.nii.ac.jp/records/2129
https://oist.repo.nii.ac.jp/records/212996bc82bb-5fa9-445e-b585-355689efcc4f
名前 / ファイル | ライセンス | アクション |
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Sassa-2021-Divalent metal transporter-related (2.1 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-05-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Divalent metal transporter-related protein restricts animals to marine habitats | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Sassa, Mieko
× Sassa, Mieko× Takagi, Toshiyuki× Kinjo, Azusa× Yoshioka, Yuki× Zayasu, Yuna× Shinzato, Chuya× Kanda, Shinji× Murakami-Sugihara, Naoko× Shirai, Kotaro× Inoue, Koji |
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書誌情報 |
en : Communications Biology 巻 4, 号 1, p. 463, 発行日 2021-04-12 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Utilization and regulation of metals from seawater by marine organisms are important physiological processes. To better understand metal regulation, we searched the crown-of-thorns starfish genome for the divalent metal transporter (DMT) gene, a membrane protein responsible for uptake of divalent cations. We found two DMT-like sequences. One is an ortholog of vertebrate DMT, but the other is an unknown protein, which we named DMT-related protein (DMTRP). Functional analysis using a yeast expression system demonstrated that DMT transports various metals, like known DMTs, but DMTRP does not. In contrast, DMTRP reduced the intracellular concentration of some metals, especially zinc, suggesting its involvement in negative regulation of metal uptake. Phylogenetic distribution of the DMTRP gene in various metazoans, including sponges, protostomes, and deuterostomes, indicates that it originated early in metazoan evolution. However, the DMTRP gene is only retained in marine species, and its loss seems to have occurred independently in ecdysozoan and vertebrate lineages from which major freshwater and land animals appeared. DMTRP may be an evolutionary and ecological limitation, restricting organisms that possess it to marine habitats, whereas its loss may have allowed other organisms to invade freshwater and terrestrial habitats. | |||||
出版者 | ||||||
出版者 | Nature Portfolio | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2399-3642 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33846549 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/s42003-021-01984-8 | |||||
権利 | ||||||
権利情報 | © 2021 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s42003-021-01984-8 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |