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Orexin-B antagonized respiratory depression induced by sevoflurane, propofol, and remifentanil in isolated brainstem-spinal cords of neonatal rats
https://kdu.repo.nii.ac.jp/records/950
https://kdu.repo.nii.ac.jp/records/950d4e12843-88e6-4f88-9984-55b488b9ea82
名前 / ファイル | ライセンス | アクション |
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Full Text(全文) (496.2 kB)
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論文内容要旨 (141.8 kB)
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論文審査要旨、最終審査の結果の要旨 (241.6 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2016-07-06 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Orexin-B antagonized respiratory depression induced by sevoflurane, propofol, and remifentanil in isolated brainstem-spinal cords of neonatal rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Anesthetics | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Animals | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Animals, Newborn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Brain Stem | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Disease Models, Animal | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Intracellular Signaling Peptides and Proteins | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Methyl Ethers | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Neuropeptides | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Orexins | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Piperidines | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Propofol | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Rats | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Rats, Wistar | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Respiratory Insufficiency | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Spinal Cord | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | 新生ラットの単離脳幹脊髄標本を用いたセボフルラン、プロポフォール、レミフェンタニルによる呼吸抑制に対するオレキシンBによる拮抗作用について | |||||
言語 | ja | |||||
著者 |
梅澤, 伸夫
× 梅澤, 伸夫× Umezawa, Nobuo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Orexins (hypocretins) play a crucial role in arousal, feeding, and endocrine function. We previously reported that orexin-B activated respiratory neurons in the isolated brainstem-spinal cords of neonatal rats. We herein determined whether orexin-B antagonized respiratory depression induced by sevoflurane, propofol, or remifentanil. We recorded C4 nerve bursts as an index of inspiratory activity in a brainstem-spinal cord preparation. The preparation was superfused with a solution equilibrated with 3% sevoflurane alone for 10 min and the superfusate was then switched to a solution containing sevoflurane plus orexin-B. Sevoflurane decreased the C4 burst rate and the integrated C4 amplitude. The C4 burst rate and amplitude were reversed by 0.5 μM orexin-B, but not by 0.1 μM orexin-B. The decrease induced in the C4 burst rate by 10 μM propofol or 0.01 μM remifentanil was significantly antagonized by 0.1 μM orexin-B. Respiratory depression induced by a higher concentration (0.1 μM) of remifentanil was not restored by 0.1 μM orexin-B. These results demonstrated that orexin-B antagonized respiratory depression induced by sevoflurane, propofol, or remifentanil. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 32703 | |||||
学位授与機関名 | 神奈川歯科大学 | |||||
学位授与年度 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2015 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-03-17 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第484号 | |||||
情報源 | ||||||
関連名称 | Respiratory Physiology & Neurobiology, 205:61-65, 2015. doi: 10.1016/j.resp.2014.10.013 | |||||
関連サイト | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.resp.2014.10.013 | |||||
関連名称 | Elsevier | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
見出し | ||||||
小見出し | PDF/A | |||||
言語 | ja |