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Total Light Approach of Time-Domain Fluorescence Diffuse Optical Tomography
https://uec.repo.nii.ac.jp/records/1145
https://uec.repo.nii.ac.jp/records/1145ac58b078-dccd-4564-bfa1-9b3c3264c744
名前 / ファイル | ライセンス | アクション |
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9000000348.pdf (3.6 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2009-03-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Total Light Approach of Time-Domain Fluorescence Diffuse Optical Tomography | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
資源タイプ | thesis | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | トータルライト法による時間分解型蛍光トモグラフィー | |||||
言語 | ja | |||||
著者 |
アンディ, マルジョノ
× アンディ, マルジョノ |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The motivation of this research is to develop a fast computation of time-domain fluorescence diffuse optical tomography but still with good image quality using the total light approach which is possible to simultaneously reconstruct the images of the fluorophore concentration and the absorption coefficient of the tissue.This dissertation consists of five chapters.Chapter 1 is the introduction to fluorescence diffuse optical tomography (FDOT). It reviews the phenomena of fluorescence from the view points of its properties and measurement methods. It also reviews diffuse optical tomography (DOT) including optical properties of tissues and photon migration inside the tissues. Combination of fluorescence and DOT leads to develop FDOT.Chapter 2 introduces the forward model using zero-lifetime emission light approach. To obtain the images of distributions of fluorophore concentrations and internal optical properties of tissue with high quality, accurate models of the forward problem to solve the propagation of excitation and emission lights in tissues are very essential. To solve these problems with a fast computation, the zero-lifetime emission light approach is introduced.Chapter 3 proposes the inverse model using the total light approach for image reconstruction and shows the reconstructed results from simulated measurement data for various objects. If the total light approach is employed in time domain FDOT, the convolution calculation to compute the emission light which is highly time-consuming in the whole reconstruction process is not necessary, and the computation time is significantly reduced. To verify fast computation but still with good image quality by use of the total light approach, simulation of time domain FDOT is performed. This chapter reviews the inversion process of reconstruction is described including generation of the Jacobian matrices and use of the algebraic reconstruction technique (ART). The last part of this chapter shows the reconstructed images under various conditions.Chapter 4 shows the experimental results to evaluate the performances of the proposed total light approach. Polyacetal cylindrical phantoms with the diameter of 28 mm and 30 mm and the length of 70 mm having the optical properties simulating the biological tissues were used in the experiment. A fluorophore solution was placed in a circular hole, with the diameter of 4 mm and the depth of 30 mm made in the phantom. Two kinds of time-resolved spectroscopic (TRS) measurement systems, single-channel and multi-channel systems, were employed.Chapter 5 presents general conclusions of the whole research. | |||||
学位名 | ||||||
学位名 | 博士(工学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 電気通信大学 | |||||
学位授与年度 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2008 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2009-03-24 |