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Epithelial-Mesenchymal Transition in Chronic Hypersensitivity Pneumonitis
https://tmdu.repo.nii.ac.jp/records/62
https://tmdu.repo.nii.ac.jp/records/622886b56b-637c-4d93-8bf1-4ff1450632a5
名前 / ファイル | ライセンス | アクション |
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04_Yasui (5.5 MB)
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Copyright © 2012 Tokyo Medical and Dental University (TMDU)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-08-07 | |||||
タイトル | ||||||
タイトル | ||||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hypersensitivity pneumonitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myofibroblast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | epithelial-mesenchymal transition | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pulmonary fibrosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | murine model | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | hypersensitivity pneumonitis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | myofibroblast | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | epithelial-mesenchymal transition | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | pulmonary fibrosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | murine model | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
安井, 牧人
× 安井, 牧人× 宮崎, 泰成× 見高, 恵子× 石塚, 聖洋× 鵜浦, 康司× 玉岡, 明洋× 角, 勇樹× 稲瀬, 直彦 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Chronic hypersensitivity pneumonitis (HP) causes progressive and irreversible pulmonary fibrosis, a disease also observed in conjunction with idiopathic pulmonary fibrosis (IPF). Previous studies have demonstrated that the myofibroblast, a cell type whose origins involve the epithelial-mesenchymal transition (EMT), may play a role in the pathogenesis of IPF. The goal of this study was to determine whether EMT has a role in the pathogenesis of chronic HP. Lung specimens from a chronic HP model and from patients with chronic HP were analyzed. Cellular co-localization of epithelial and mesenchymal markers on the same alveolar epithelial cells (AECs) were examined using immunohistochemistry and cadherin switching by western blotting as indicators of EMT. EMT cells in the AECs were significantly more prevalent in lung specimens from Th2-prone A/J mice than in specimens from Th1-prone C57BL/6 mice. The percentage of EMT cells was correlated with the mRNA expressions of IL-13 and TGF-β1, the fibrosis score, and the collagen content in the A/J mice. In human, EMT cells in the AECs were significantly more prevalent in lungs specimens from patients with usual interstitial pneumonia pattern than in specimens from patients with nonspecific interstitial pneumonia pattern at the moderate stage of fibrosis. In conclusion, EMT may play an important role in the fibrotic process of chronic HP under the Th2-biased environment. | |||||
書誌情報 |
Journal of medical and dental sciences en : Journal of medical and dental sciences 巻 59, 号 1, p. 29-41, 発行日 2012-03 |
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出版者 | ||||||
出版者 | 国立大学法人 東京医科歯科大学 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2185-9132 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12028964 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110008904368 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 23896962 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.11480/jmds.590104 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |