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Whole-blood platelet aggregation by Porphyromonas gingivalis in patients with peripheral arterial disease
https://tmdu.repo.nii.ac.jp/records/66
https://tmdu.repo.nii.ac.jp/records/6627cf7d64-45b8-46dc-ac86-38f1583269be
名前 / ファイル | ライセンス | アクション |
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02_Notani (1.1 MB)
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Copyright © 2011 Tokyo Medical and Dental University (TMDU)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-08-07 | |||||
タイトル | ||||||
タイトル | ||||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | peripheral arterial disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Porphyromonas gingivalis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | whole-blood platelet aggregation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | peripheral arterial disease | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Porphyromonas gingivalis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | whole-blood platelet aggregation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
野谷, 啓之
× 野谷, 啓之× 井上, 芳徳× 菅野, 範英× 地引, 政利× 梅田, 誠× 和泉, 雄一 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives: To measure platelet aggregation promoted by Porphyromonas gingivalis ( P. gingivalis ) in whole blood, and to investigate the relation between P. gingivalis and peripheral arterial disease (PAD). Methods and Results: Subjects were 30 patients who were diagnosed as having PAD (PAD Group), and 26 healthy adults without subjective symptoms or arteriosclerosis as a control (Control Group). PAD patients were classified depending on severity levels by Fontaine classification or toe pressure (TP). Twelve-minute changes of electrical impedance after adding P. gingivalis to whole blood was 10.2 ± 4.8 (range, 5.1-14.3) ohm in PAD Group, and 6.1 ± 5.6 (range, 0.2-10.8) ohm in Control Group. PAD Group showed significantly stronger whole-blood platelet aggregation by P. gingivalis . The patients with more severe PAD showed stronger whole-blood platelet aggregation by P. gingivalis . PAD Group had significantly higher serum IgG against P. gingivalis titers than Control Group. In PAD patients with teeth, there was a strong positive correlation between wholeblood platelet aggregation and IgG against P. gingivalis titers. Conclusions: Platelet aggregation promoted by P. gingivalis was significantly high in PAD patients, and was related to the deterioration of their symptoms even in whole blood, which was the environment closer to physiological conditions. | |||||
書誌情報 |
Journal of medical and dental sciences en : Journal of medical and dental sciences 巻 58, 号 1, p. 7-14, 発行日 2011-03 |
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出版者 | ||||||
出版者 | 国立大学法人 東京医科歯科大学 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2185-9132 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12028964 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110008379639 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 23896781 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.11480/jmds.580102 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |