WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "cfbce91f-6107-4127-a07f-47f9d4bfc558"}, "_deposit": {"created_by": 11, "id": "90", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "90"}, "status": "published"}, "_oai": {"id": "oai:tmdu.repo.nii.ac.jp:00000090", "sets": ["57"]}, "author_link": ["832", "830", "825", "853", "838", "849", "850", "544", "847", "827", "846", "831"], "item_10002_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "175", "bibliographicPageStart": "165", "bibliographicVolumeNumber": "57", "bibliographic_titles": [{"bibliographic_title": "Journal of Medical and Dental Sciences"}, {"bibliographic_title": "Journal of medical and dental sciences", "bibliographic_titleLang": "en"}]}]}, "item_10002_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Purpose: We investigated the significance of CD24 and CD44 expression for predicting responses to chemotherapy and prognosis in primary breast cancer patients. Patients and Methods: Diagnosis of breast cancer was confirmed by core needle biopsy, and immunohistochemical studies were performed. Preoperatively, patients received anthracyclinecontaining chemotherapy. Expression of CD44 and CD24 was assessed immunohistochemically and the relationship with chemotherapy response and with prognosis was analyzed. Results : Between 2001 and 2004, 139 women were enrolled in this study. In the correlation analysis, CD24 expression was negatively associated with pathological response to chemotherapy (p=0.0003). A machine learning technique with an alternating decision tree (ADTree) showed that four logical rules are involved in predicting the response depending on the combination of CD24, HER2, tumor stage, CD44, progesterone receptor, and patient age. In the survival analysis, patients having CD44 (++) showed a significantly favorable prognosis as compared with others (p=0.0002). A multivariate analysis showed that CD44 expression had an independent prognostic value (p\u003c0.001). Conclusion : We found a significant correlation between CD44 expression and prognosis and between CD24 expression and response to chemotherapy. CD24 and CD44 expressions would be useful predictive markers, although further studies are needed. ", "subitem_description_type": "Abstract"}]}, "item_10002_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "国立大学法人 東京医科歯科大学"}]}, "item_10002_relation_12": {"attribute_name": "論文ID(NAID)", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "110007617721", "subitem_relation_type_select": "NAID"}}]}, "item_10002_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "21073135", "subitem_relation_type_select": "PMID"}}]}, "item_10002_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.11480/jmds.570206", "subitem_relation_type_select": "DOI"}}]}, "item_10002_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12028964", "subitem_source_identifier_type": "NCID"}]}, "item_10002_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2185-9132", "subitem_source_identifier_type": "ISSN"}]}, "item_10002_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "堀口, 和美"}, {"creatorName": "Horiguchi, Kazumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "838", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "戸井, 雅和"}, {"creatorName": "Toi, Masakazu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "831", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "堀口, 慎一郎"}, {"creatorName": "Horiguchi, Shin-ichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "825", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "杉本, 昌弘"}, {"creatorName": "Sugimoto, Masahiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "846", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "内藤, 泰宏"}, {"creatorName": "Naito, Yasuhiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "847", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "林, 幸子"}, {"creatorName": "Hayashi, Yukiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "827", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "上野, 貴之"}, {"creatorName": "Ueno, Takayuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "849", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "大野, 真司"}, {"creatorName": "Ohno, Shinji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "850", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "船田, 信顕"}, {"creatorName": "Funata, Nobuaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "832", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "黒井, 克昌"}, {"creatorName": "Kuroi, Katsumasa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "830", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "冨田, 勝"}, {"creatorName": "Tomita, Masaru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "853", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "江石, 義信"}, {"creatorName": "Eishi, Yoshinobu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "544", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "06_K.Horiguchi.pdf", "filesize": [{"value": "975.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Copyright © 2010 Tokyo Medical and Dental University (TMDU) ", "licensetype": "license_free", "mimetype": "application/pdf", "size": 975100.0, "url": {"label": "06_K.Horiguchi", "url": "https://tmdu.repo.nii.ac.jp/record/90/files/06_K.Horiguchi.pdf"}, "version_id": "5a79ef38-8bb7-4b9c-84fa-e4ce633892f0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "breast cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD24", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD44", "subitem_subject_scheme": "Other"}, {"subitem_subject": "response", "subitem_subject_scheme": "Other"}, {"subitem_subject": "prognosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "breast cancer", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD24", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD44", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "response", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "prognosis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Predictive value of CD24 and CD44 for neoadjuvant chemotherapy response and prognosis in primary breast cancer patients", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Predictive value of CD24 and CD44 for neoadjuvant chemotherapy response and prognosis in primary breast cancer patients"}, {"subitem_title": "Predictive value of CD24 and CD44 for neoadjuvant chemotherapy response and prognosis in primary breast cancer patients", "subitem_title_language": "en"}]}, "item_type_id": "10002", "owner": "11", "path": ["57"], "permalink_uri": "https://tmdu.repo.nii.ac.jp/records/90", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-08-07"}, "publish_date": "2017-08-07", "publish_status": "0", "recid": "90", "relation": {}, "relation_version_is_last": true, "title": ["Predictive value of CD24 and CD44 for neoadjuvant chemotherapy response and prognosis in primary breast cancer patients"], "weko_shared_id": -1}
Predictive value of CD24 and CD44 for neoadjuvant chemotherapy response and prognosis in primary breast cancer patients
https://tmdu.repo.nii.ac.jp/records/90
https://tmdu.repo.nii.ac.jp/records/901c1f6f0e-81c6-4403-92a4-504e04d14ef4
名前 / ファイル | ライセンス | アクション |
---|---|---|
06_K.Horiguchi (975.1 kB)
|
Copyright © 2010 Tokyo Medical and Dental University (TMDU)
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-08-07 | |||||
タイトル | ||||||
タイトル | ||||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | breast cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD24 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD44 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | response | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | prognosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | breast cancer | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | CD24 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | CD44 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | response | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | prognosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
堀口, 和美
× 堀口, 和美× 戸井, 雅和× 堀口, 慎一郎× 杉本, 昌弘× 内藤, 泰宏× 林, 幸子× 上野, 貴之× 大野, 真司× 船田, 信顕× 黒井, 克昌× 冨田, 勝× 江石, 義信 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: We investigated the significance of CD24 and CD44 expression for predicting responses to chemotherapy and prognosis in primary breast cancer patients. Patients and Methods: Diagnosis of breast cancer was confirmed by core needle biopsy, and immunohistochemical studies were performed. Preoperatively, patients received anthracyclinecontaining chemotherapy. Expression of CD44 and CD24 was assessed immunohistochemically and the relationship with chemotherapy response and with prognosis was analyzed. Results : Between 2001 and 2004, 139 women were enrolled in this study. In the correlation analysis, CD24 expression was negatively associated with pathological response to chemotherapy (p=0.0003). A machine learning technique with an alternating decision tree (ADTree) showed that four logical rules are involved in predicting the response depending on the combination of CD24, HER2, tumor stage, CD44, progesterone receptor, and patient age. In the survival analysis, patients having CD44 (++) showed a significantly favorable prognosis as compared with others (p=0.0002). A multivariate analysis showed that CD44 expression had an independent prognostic value (p<0.001). Conclusion : We found a significant correlation between CD44 expression and prognosis and between CD24 expression and response to chemotherapy. CD24 and CD44 expressions would be useful predictive markers, although further studies are needed. | |||||
書誌情報 |
Journal of Medical and Dental Sciences en : Journal of medical and dental sciences 巻 57, 号 2, p. 165-175, 発行日 2010-06 |
|||||
出版者 | ||||||
出版者 | 国立大学法人 東京医科歯科大学 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2185-9132 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12028964 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110007617721 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21073135 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.11480/jmds.570206 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |