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The descending antinociceptive system (DAS) is an important component of the DNIC neural network, but the precise structure of the neural network and the related neurotransmitters have not been examined. Methods: The study was designed to examine whether systemic administration of the adrenergic agonists dexmedetomidine (DEX) and phenylephrine (PE) influences DNIC in the rat. Changes in the C-fiber reflex evoked by electromyographic activity were recorded following noxious tail immersion in hot water. Results: Inhibition of the C-fiber reflex by the conditioning stimuli was reduced from 77.1 ± 22.6% to 26.6 ± 38.2% with continuous administration of DEX, and restored to 58.3 ± 29.2% by intramuscular injection of atipamezole hydrochloride(APZ), a selective α 2- adrenoceptor antagonist. 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Effects of alpha-adrenergic agonists on pain modulation in diffuse noxious inhibitory control
https://tmdu.repo.nii.ac.jp/records/114
https://tmdu.repo.nii.ac.jp/records/114980d8c10-e576-45b9-b1a1-5920d8fad992
名前 / ファイル | ライセンス | アクション |
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02_sanada (316.5 kB)
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Copyright © 2009 Tokyo Medical and Dental University (TMDU)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-08-08 | |||||
タイトル | ||||||
タイトル | ||||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Diffuse noxious inhibitory control | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dexmedetomidine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | phenylephrine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pain modulation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | descending antinociceptive system | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Diffuse noxious inhibitory control | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | dexmedetomidine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | phenylephrine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | pain modulation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | descending antinociceptive system | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
真田, 達夫
× 真田, 達夫× 小長谷, 光× 牧野, 兼三× 海野, 雅浩 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Diffuse noxious inhibitory control (DNIC) is thought to be mediated by neural networks in supraspinal brain structures. The descending antinociceptive system (DAS) is an important component of the DNIC neural network, but the precise structure of the neural network and the related neurotransmitters have not been examined. Methods: The study was designed to examine whether systemic administration of the adrenergic agonists dexmedetomidine (DEX) and phenylephrine (PE) influences DNIC in the rat. Changes in the C-fiber reflex evoked by electromyographic activity were recorded following noxious tail immersion in hot water. Results: Inhibition of the C-fiber reflex by the conditioning stimuli was reduced from 77.1 ± 22.6% to 26.6 ± 38.2% with continuous administration of DEX, and restored to 58.3 ± 29.2% by intramuscular injection of atipamezole hydrochloride(APZ), a selective α 2- adrenoceptor antagonist. Inhibition of the C-fiber reflex was reduced from 75.6 ± 25.8% to 22.7 ± 38.9% with continuous administration of PE, and restored to 84.9 ± 9.7% by intramuscular injection of phentolamine mesylate (PT), an α - adrenoceptor antagonist. Conclusion: The results show that clinical doses of DEX and PE inhibit DNIC, thereby aff ecting and modulating the intrinsic pain inhibition system. These findings suggest that adrenergic neurons are involved in DNIC. | |||||
書誌情報 |
Journal of Medical and Dental Sciences en : Journal of Medical and Dental Sciences 巻 56, 号 1, p. 17-24, 発行日 2009-03 |
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出版者 | ||||||
出版者 | 国立大学法人 東京医科歯科大学 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2185-9132 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12028964 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 130005420266 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19697515 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.11480/jmds.560102 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |