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Micro-CT evaluation of tooth, calvaria and mechanical stress-induced tooth movement in adult Runx2/Cbfa1 heterozygous knock-out mice
https://tmdu.repo.nii.ac.jp/records/242
https://tmdu.repo.nii.ac.jp/records/242913c03b0-5a6d-4e79-a334-2bae46deffe3
名前 / ファイル | ライセンス | アクション |
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14_chung (1.2 MB)
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Copyright © 2004 Tokyo Medical and Dental University (TMDU)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-08-15 | |||||
タイトル | ||||||
タイトル | ||||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Runx2/Cbfa1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mechanical stress | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tooth | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | calvaria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tooth movement | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Runx2/Cbfa1 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mechanical stress | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | tooth | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | calvaria | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | tooth movement | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
鄭, 朱玲
× 鄭, 朱玲× 辻, 邦和× 二藤, 彰× 小守, 壽文× 相馬, 邦道× 野田, 政樹 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Runx2/Cbfa1 is essential for osteoblast differentiation and bone formation. Runx2 null mice (Runx2-/-) completely lack mineralized tissue and die soon after birth, whereas Runx2 heterozygous knock-out mice (Runx2+/-) stay alive but show morphological defects in the skeletal system as observed in cleidocranial dysplasia (CCD) in humans. The aim of this study is to elucidate the role of Runx2 in adult mineralized tissue and also to reveal the distinct features of heterozygous deletion of Runx2 in response to tooth movement. Therefore, we examined the cranium, tooth and the periodontium in adult Runx2+/- using soft X-ray and micro-CT. In addition, tooth movement induced by mechanical loading was evaluated. In adult Runx2+/-, crown: root ratio of the first maxillary molar was significantly lower than that of wild type (WT). Irregularities in root morphology was also observed. The cranium was narrow with thin parietal bone compared to WT. Mechanical stressinduced tooth movement was similar between Runx2+/- and WT in terms of movement distance. However, while rotational movement between the first and third week was increased in WT, it was not altered in Runx2+/- mice. These data indicate that Runx2 plays a role in cranium and the tooth development in adulthood. | |||||
書誌情報 |
Journal of Medical and Dental Sciences en : Journal of medical and dental sciences 巻 51, 号 1, p. 105-113, 発行日 2004-03 |
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出版者 | ||||||
出版者 | 東京医科歯科大学 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2185-9132 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12028964 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110000076058 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 15137472 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.11480/jmds.510114 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |