WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "6efa6465-ba60-43c2-9690-5e52dba5fb66"}, "_deposit": {"created_by": 11, "id": "450", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "450"}, "status": "published"}, "_oai": {"id": "oai:tmdu.repo.nii.ac.jp:00000450", "sets": ["130"]}, "author_link": ["4071", "4072", "4073", "4074"], "control_number": "450", "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "30", "bibliographicPageStart": "23", "bibliographicVolumeNumber": "66", "bibliographic_titles": [{"bibliographic_title": "Journal of Medical and Dental Sciences"}]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Eukaryotic cells, when exposed to stress, stop protein translation and form cytoplasmic granules called stress granules (SGs) containing mRNAs and mRNA-binding proteins such as Ras-GAP SH3 domain-binding protein (G3BP) 1 and 2. Cells are thought to survive stress by utilizing SGs as the platform of RNA triage. Accordingly, in cancer cells, SGs are proposed to cause resistance against anti-cancer drugs. We initiated this study to identify novel compounds that induce SGs. We exposed human keratinocyte HaCaT cells to various chemical compounds and immunostained them with anti-G3BP antibody. We found that the cells exposed to topoisomerase inhibitors, teniposide and topotecan, form G3BP-containing aggregates (GCAs). GCAs look like SGs, but are formed more slowly and are not dissociated after stress removal. GCA formation is not associated with eIF2α phosphorylation, while in most cases SG formation depends on it. More importantly, GCAs do not contain representative components of SGs or mRNAs. In sum, we have unexpectedly found a novel cytoplasmic structure containing G3BP that is distinct from SG.", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Tokyo Medical and Dental University"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.11480/jmds.01", "subitem_relation_type_select": "DOI"}}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright ©2019 Tokyo Medical and Dental University (TMDU)"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2185-9132", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Qiu, Wenzhe"}], "nameIdentifiers": [{"nameIdentifier": "4071", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arimoto-Matsuzaki, Kyoko"}], "nameIdentifiers": [{"nameIdentifier": "4072", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Masami"}], "nameIdentifiers": [{"nameIdentifier": "4073", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hata, Yutaka"}], "nameIdentifiers": [{"nameIdentifier": "4074", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "コンテンツ本体", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "01_Qiu.pdf", "filesize": [{"value": "969.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Copyright ©2019 Tokyo Medical and Dental University (TMDU)", "licensetype": "license_free", "mimetype": "application/pdf", "size": 969800.0, "url": {"label": "01_Qiu", "url": "https://tmdu.repo.nii.ac.jp/record/450/files/01_Qiu.pdf"}, "version_id": "bfe26495-0848-4ea3-b09b-15ba86fa53b4"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "G3BP", "subitem_subject_scheme": "Other"}, {"subitem_subject": "drug resistance", "subitem_subject_scheme": "Other"}, {"subitem_subject": "stress granules", "subitem_subject_scheme": "Other"}, {"subitem_subject": "topoisomerase inhibitor", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Human keratinocyte HaCaT cells form aggregates containing Ras-GAP SH3 domain-binding proteins in the cytoplasm in response to a low dose of teniposide", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Human keratinocyte HaCaT cells form aggregates containing Ras-GAP SH3 domain-binding proteins in the cytoplasm in response to a low dose of teniposide", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "11", "path": ["130"], "permalink_uri": "https://tmdu.repo.nii.ac.jp/records/450", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-06-24"}, "publish_date": "2019-06-24", "publish_status": "0", "recid": "450", "relation": {}, "relation_version_is_last": true, "title": ["Human keratinocyte HaCaT cells form aggregates containing Ras-GAP SH3 domain-binding proteins in the cytoplasm in response to a low dose of teniposide"], "weko_shared_id": -1}
Human keratinocyte HaCaT cells form aggregates containing Ras-GAP SH3 domain-binding proteins in the cytoplasm in response to a low dose of teniposide
https://tmdu.repo.nii.ac.jp/records/450
https://tmdu.repo.nii.ac.jp/records/4502e117689-db82-42fc-bc73-32755b092524
名前 / ファイル | ライセンス | アクション |
---|---|---|
01_Qiu (969.8 kB)
|
Copyright ©2019 Tokyo Medical and Dental University (TMDU)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-06-24 | |||||
タイトル | ||||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | G3BP | |||||
キーワード | ||||||
主題 | drug resistance | |||||
キーワード | ||||||
主題 | stress granules | |||||
キーワード | ||||||
主題 | topoisomerase inhibitor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Qiu, Wenzhe
× Qiu, Wenzhe× Arimoto-Matsuzaki, Kyoko× Kitamura, Masami× Hata, Yutaka |
|||||
抄録 | ||||||
書誌情報 |
Journal of Medical and Dental Sciences 巻 66, 号 2, p. 23-30, 発行日 2019-06 |
|||||
出版者 | ||||||
出版者 | Tokyo Medical and Dental University | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2185-9132 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.11480/jmds.01 | |||||
権利 | ||||||
権利情報 | Copyright ©2019 Tokyo Medical and Dental University (TMDU) | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |