WEKO3
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Inhibitory effect of apicidin on in vitro and in vivo growth of Babesia parasites
https://obihiro.repo.nii.ac.jp/records/1464
https://obihiro.repo.nii.ac.jp/records/146469c269a6-ca25-466c-87e2-2b9abbfa323a
名前 / ファイル | ライセンス | アクション |
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v19-42-49.pdf (207.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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公開日 | 2009-10-01 | |||||||||||||
タイトル | ||||||||||||||
言語 | en | |||||||||||||
タイトル | Inhibitory effect of apicidin on in vitro and in vivo growth of Babesia parasites | |||||||||||||
言語 | ||||||||||||||
言語 | eng | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Apicidin | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | B .bovis | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | B .bigemina | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | B. microti | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | asexual growth | |||||||||||||
資源タイプ | ||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
資源タイプ | journal article | |||||||||||||
著者 |
Munkhjargal, T
× Munkhjargal, T× Aboulaila, M.R.A× Sivakumar, Thillaiampalam× 横山, 直明
WEKO
312
× 五十嵐, 郁男
WEKO
58
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抄録 | ||||||||||||||
内容記述タイプ | Abstract | |||||||||||||
内容記述 | Apicidin, a histone deacetylase inhibitor, has a broad spectrum of anti-protozoal activities against apicomplexan parasites. In the present study, we evaluated the inhibitory effect of apicidin on the asexual growth of bovine Babesia parasites (B. bovis and B. bigemina) in vitro, as well as on the in vivo growth of B. microti in mice. The growth of B. bovis and B. bigemina was significantly inhibited in the presence of 3 ng/ml apicidin. Complete inhibition of B. bovis and B. bigemina growth was achieved on the fourth and third days, respectively, after treatment with 729 ng/ml apicidin. These parasites failed to grow again even when drug-free medium was substituted. The 50% inhibitory concentrations of apicidin against B. bovis and B. bigemina were determined as 7.1 and 20.7 ng/ml, respectively, in in vitro cultures with serum-containing M199 medium. Severe morphological signs of damage, such as pyknotic and degenerative changes, were observed in the treated parasites. Apicidin 2 mg/kg caused significant inhibition of B. microti growth and altered the parasitemia dynamics in mice, compared with untreated control mice. Apicidin could be an effective chemotherapeutic agent for the treatment of bovine and human babesioses. | |||||||||||||
言語 | en | |||||||||||||
書誌情報 |
en : The journal of protozoology research 巻 19, 号 1, p. 42-49, 発行日 2009-06 |
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出版者 | ||||||||||||||
言語 | en | |||||||||||||
出版者 | National Research Center for Protozoan Diseases | |||||||||||||
ISSN | ||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||
収録物識別子 | 09174427 | |||||||||||||
書誌レコードID | ||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||
収録物識別子 | AA10824856 | |||||||||||||
権利 | ||||||||||||||
言語 | en | |||||||||||||
権利情報 | National Research Center for Protozoan Diseases | |||||||||||||
フォーマット | ||||||||||||||
内容記述タイプ | Other | |||||||||||||
内容記述 | application/pdf | |||||||||||||
著者版フラグ | ||||||||||||||
出版タイプ | VoR | |||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
日本十進分類法 | ||||||||||||||
主題Scheme | NDC | |||||||||||||
主題 | 649 |